Multisystem Functional Improvement After NAD⁺-Supported Allogeneic Human Mesenchymal Stem Cell Infusion in a Middle-Aged Male with Hypertension, Anxiety, Sleep Deprivation, and Chronic Fatigue: A Case Report
October 31, 2025 - Published Multisystem Functional Improvement After NAD⁺-Supported Allogeneic Human Mesenchymal Stem Cell Infusion in a Middle-Aged Male with Hypertension, Anxiety, Sleep Deprivation, and Chronic Fatigue: A Case Report Daryl Joel Dumdum, MD, DFM Sure Health 360 Research Institute, 10th Floor Lanang Premier Doctors Hospital Inc, Davao City Philippines Abstract Background: Allogeneic human mesenchymal stem cells (hMSCs) are increasingly explored for their immunomodulatory, anti-inflammatory, and pro-repair effects in chronic functional syndromes characterized by fatigue, stress dysregulation, metabolic strain, and pain. Adjunctive metabolic optimization using NAD⁺-based infusion therapy and peptide/nutrient support is hypothesized to improve cellular environment and reduce background inflammation before stem cell administration. Case Presentation: A 45-year-old male presented with moderate generalized anxiety, uncontrolled hypertension, chronic fatigue, muscu...